Cloning Essays (437 words) - Cloning, Molecular Biology, Genetics

Cloning Essays (437 words) - Cloning, Molecular Biology, Genetics Cloning Cloning Today During my interview with my grandmother I asked her what she thought of cloning. she responded by saying that it was not right and should be stopped. on the other hand i have a different opinion. I think that cloning should be continued and furhter researched for we might be able to have different organs and substances produced in these clones. Below is the step that were taken to clone the adult sheep named Dolly. Part 1: An Improbable Goal Scientists hoped that cloning healthy, mature sheep, rather than just creating lambs from embryonic cells, could produce a highly specialized sheep with large quantities of proteins in its milk. The proteins are believed to help treat diseases such as emphysema, hemophylia and cystic fibrosis. Part 2: The Perfect Timing For years, scientists could not synchronize the growth of the egg and the cell. If one was off- synch, abnormal chromosomes would soon transform in the nucleus and thereby kill off the embryo. Dr. Wilmut achieved near perfection in the timing by putting the cells into hybernation; of the 277 eggs they began with, 247 lived through the process. Timing the growth in other species, however, has proved to scientists that cloning mature animals is extremely difficult; in the case of mice, they've concluded it can't be accomplished. Part 3: Jump-start from a Jolt Though it has become a standard procedure in cloning, scientists are not sure why an electric pulse sent to the two cells causes them to meld together and activates development in the egg. They are learning, however, the shock doesn't fully mimic the activation process of a sperm, which could explain why just 29 of the remaining 247 cells live longer than six days. Part 4: Surrogate Motherhood Despite the fact that the newly formed embryo is transplanted into the uterus of another ewe, scientists believe Dolly is a nearly exact carbon-copy of her genetic originating mother. In theory, that means an almost exact look-alike of John F. Kennedy Jr. could be produced by taking cells from his skin, melding their nuclei with any woman's egg that has had its nucleus removed and then planting the embryo in a surrogate mother. Part 5: A 6-Year-Old in 7 Months? Scientists are eagerly watching Dolly to see if she exhibits the characteristics of her mother, a 6-year-old sheep, or those of her own age, just 7 months. As animals and humans age, changes occur in their DNA - such as decreasing fertility and increasing susceptibility to cancer and other diseases. If she prematurely ages, clones of mature animals would be useless to the agriculture industry.

Object oriented development Essay Example | Topics and Well Written Essays - 1250 words

Object oriented development - Essay Example It is an easier way to keep track of program flow and much organized than the traditional "spaghetti codes" produced by unstructured programming methods. In 70's, a new programming technique began to gain popularity as a "top-down" approach to program design. This is a technique where a program designer maps out large-scale structure of a program and breaks them into smaller operations. These smaller operations will be tested or debug separately and connect them together into the entire program. Structured programming facilitates easy understanding of smaller pieces of code without having to understand the whole program at once. By the end of the 20th century, mainstream programmers realized the significance and value of structured approach began to apply the concept in high-level programming languages. In the middle of the 1980's, another concept in program development made its way to become the dominant programming methodology. Mainly influenced by C++ and the popularity of GUI (Graphical User Interface), Object-oriented programming became the most sought after programming method to date. The objective behind object-oriented programming is to view computer programs as a collection of individual units or objects that is capable of receiving messages, processing data, and sending messages to each other. This is different from the belief and practice that a program is just a compilation of functions and procedures or a list of commands for a computer to follow. Object-oriented programming is broadly accepted in large-scale software development. It is adaptable, easy to learn, simpler to develop and maintain, and easier to manage. The fundamental concepts of OOP (short for object oriented programming) are class, object, encapsulation, inheritance, abstraction, and polymorphism. Class is a unit of data and function for a particular thing. For instance, a "class of students" might be a set, which include different type of students (male, female, black, white etc.). An Object is an occurrence of a class, a run-time demonstration of a specific pattern of a class. For instance, the gender "male" and "female" as a subclass and "Alfred" the student as an object in the class of students. Encapsulation is a type of privacy to ensure that an object can be change only through established channels within a class. It simply means packaging the data and related functions into one unified unit, a class. Inheritance- is a mechanism for creating subclasses; it provides a way to define a subclass or an extension of a universal class. For instance, as students, class is a subclass of year level class and gender of student in a class is a subclass of the class students. An Abstraction is the ability of a program to disregard the details of an object's class or subclass and si mplify it into a more suitable general level. For instance, "Alfred" the students may be abstracted to a more generic level as year level super class. Polymorphism is a varying behaviour depending on the class in which the behaviour is call upon to act. This is to say that two or more classes can answer independently and in an entirely different way to an identical message. THE EVOLUTION OF OBJECT-ORIENTED PHP Not too many people know that PHP, the popular and powerful web base scripting language, coined in the summer

Kant - Three Propositions from Groundwork of the Metaphysics of Morals Essay

Kant - Three Propositions from Groundwork of the Metaphysics of Morals - Essay Example In his second proposition, Kant iterates that the moral worth of an action derives from its maxim and not from its consequences. In further deliverance of this notion, Kant determines that a prescribed action done from duty is determined in its moral worth only by virtue of the principle, or maxim, in â€Å"accordance with which it is decided upon†. This implies that the moral worth of the will to do an action lies NOT in its motive or the desired effect from that action, but in the actual principle of the will. In Kant’s view, a will is genuine and morally sound if it is derived from duty alone instead of any ancillary motive where duty simply plays a complementary role instead of being the motivating factor in its entirety. Thus, it must necessarily follow that the person taking the action has recognized an a priori goodwill principle that they seek to fulfill by taking that action; thus, the action has been brought about from duty instead of being committed for a pur pose beyond that which imposed by the goodwill, rendering it of sound moral worth. Kant recognizes a third proposition in a similar way which at first seems like in stark contrast to his second proposition but in essence, follows through with the same elements of rationality by inciting a â€Å"respect for law† which imposes a duty to respect the moral law.... Such morality requires a conception of reason, which in normal daily lives goes well beyond our basic desires. In these arguments, Kant sets out to establish the foundational principle of a set of morals. What he is trying to show is that this foundational moral principle draws from a rational will in all of us, and it is this rational will that makes us possess the autonomy to act morally. This autonomy is essentially derived from duty and has the capability of denouncing all inclinations (second proposition) in order to pursue actions that are done strictly in respect of moral law (third proposition). As he rounds up his arguments in this work, he puts it clearly that there are universal moral laws, and any action that is agreeable should not only obey a moral law, but should be done to ensure morality is upheld (Kant 4:400). Any action that is not done for the sake of a moral law even if it conforms to a moral law is not logically necessary. Thus, it is prudent to observe and link the second and third propositions in pursuit of the universal law of morals. Kant seems to maintain that the second proposition is directly linked with the third proposition. However, the notion of respect seems to suggest otherwise as it exists in the third and not in the second proposition. What, then, is respect? Respect is a notion unhinged to the personal faculty of desire and is therefore not an inclination. In plain English, thus, respect is an attitude which impels goodwill actions. An action done by reason of inclination, as opposed to one by reason of respect, would seek a desired effect, and is NOT an action from duty, but an action for a purpose. This brings us to a consideration of the

Technology In The Workplace Essay Example for Free

Technology In The Workplace Essay In my workplace, an acute care hospital with 968 beds and a workforce of approximately 5,000 employees, technology is a huge part of the operations.   As a matter of fact, technology has become necessary and fundamental not only in the usual day-to-day activities of the hospital like keeping patients’ medical records, doctors’ schedules, employees’ salaries and the like, but also as an added accommodation for patients who have special needs or requests. The operating systems used are Microsoft Windows (Windows 2000 and Windows XP Professional) and the Macintosh Operating System to avoid a sense of monopoly and hence providing a choice for the users, depending on which system they are more familiar with or which one better serves their needs.    For example, Apple Macintosh is preferred over IBM computers by some physicians for research purposes and further education in the medical field. The functionality of computers is extended from just being a set of relational databases because it can be maximized further to the benefit of both the hospital and the patients.   Since all areas of the hospital are equipped with computers that have ready access to the Internet, the inter-connectivity is taken advantage of in many ways. Networks are established within the workplace to have an easier access to information in and out of the company.   Cisco router is used for broad infrastructure and the Nortel network for remote access.   For patient documentation from multi-disciplinary venues, the UNIX server and the Sunrise Clinical Manager are used.   All patients and vendors have can have unlimited access to the Guest Wireless network through a code that can be obtained after signing up with the IT Department. Although previously used mostly in business establishments and big hotels, audio/video conferencing is also presently being provided by our hospital.   In one instance, the daughter of one of our female patients was getting married in another state.   Unfortunately, her mother was hospitalized and was therefore unable to attend the ceremony.   Knowing that this was one occasion the mother would not want to miss, the system was set up in her room where she could view the wedding and hear what was going on.   At the same time, the bride and groom could see and hear her.   The patient even dressed up for the occasion while the hospital staff provided flowers and the hospital’s communication department took charge of the hook-up. Furthermore, the hospital has a secured website that allows virtual private remote access.   The hospital employees can easily access a site to view their pays tubs.   For the public, a site provides information on the hospital’s roster of doctors and their specializations, the types of health services available including outpatient services, and general information about the hospital. In addition to all these, the hospital has two (2) patient channels from which they could view chapel services or listen to soft music while viewing scenes that allows meditation, prayer or just plain mental relaxation.   These are exclusively for in-patients’ use and are not available to the public outside the hospital. The hospital is also a teaching facility for would-be doctors and nurses but at present, it does not fully provide distance education.   It has links to the Medical Library for the use of its students and the hospital personnel, but it does not have computer-based academic programs that provide full education. Essentially, with the advent of technology, the hospital has become more than just a place where sick people go for treatment.   It has also become a sanctuary for the sick where they could listen to soothing music or take part in religious services without having to leave their hospital bed.

Middle Age Entertainers :: Art

Middle Age Entertainers Both entertainment and education have been integrals parts of the human experience since the beginnings of time. Many scholars insist that the two institutions often serve jointly, with entertainers and entertainment serving as a main source of education. There is little argument, then, that in addition to generally appealing to the masses, entertainers have regularly fulfilled the role of a teacher to typically unsuspecting audiences. Entertainers have served as educators throughout history, from the origins of oral narratives through the Middle Ages. The earliest forms of unwritten communication were essentially used to spread knowledge from one source to another. Religious disciplines were the first information passed from person to person through entertainment. In the third century B.C., Buddhist monks tried to win converts outside India through the use of theater and song (Burdick 97). They taught the precepts of Siddhartha and Buddha in such theatrical epics as Ramayana and Mahabharata, setting exacting rules for theater performance in the process (Burdick 99). Similarly, Irish monks established singing schools, which taught uniform use of music throughout the church (Young 31). Through chants which were all the same, they spread identical teachings. Christian psalms and hymns in Apostolic times were sung to spread the knowledge and faith of Christianity. In fact, Christianity was promoted from the start by music. Churches were for long the only centers of learning, with monks teaching all lessons through music (Young 39). Through the use of sacred music, monks and clergy successfully spread the teachings of their religions in a practical manner. Entertainers used the theater as a place to tell the stories of the day, both fictional and topical. The African oral tradition was rich in folk tales, myths, riddles, and proverbs, serving a religious, social, and economic function (Lindfors 1). Likewise, Asian actors covered their faces with masks in order to act out a scandal of the day without the audience knowing who was passing along the gossip (Archer 76). European puppets were another medium which permitted entertainers to spread current gossip without revealing the identity of the storyteller (Speaight 16). The theatrical productions of the Greeks further explored the use of theater as an instructional tool. Because the theater provided such a diverse forum for expression, stage actors and playwrights consistantly utilized this locale to eduate the general public. Oral communication was widely used to educate society about morals and basic truths.

Stefan’s Diaries: Bloodlust Chapter 27

My heavy-lidded eyes fought to drift open. I didnt know how much time had passed. Was it one night? Two? A week? It was dark, wherever I was. I was vaguely conscious, hearing footfalls and yelling, and once a voice that sounded like Callies, calling out my name. But one day I woke up without suddenly falling back into unconsciousness. I lifted my arms, realizing I was shackled to the wall. I had vervain burns on my arms and legs. Dried blood crusted my entire body, making it impossible for me to tell where I was wounded. Next to me, Damon was sitting with his knees to his chest. Blood covered his body, and his cheeks were gaunt. Dark shadows rimmed his sunken eyes, but a slow smile was spreading across his face. â€Å"Not so powerful now, are you, brother?† I struggled to sit up. My bones ached. The attic was soaked in a dim gray light that came from a filthy window. The padding and sniffing of a mouse sounded somewhere far across the room. It stirred a hunger inside me, and I realized that I hadnt fed since being here. In the corner, two unfamiliar guards were sitting, oblivious to our near-silent conversation. I shook my head in disgust. How could I have been so stupid? Lexi had been right. Of course she had. Callie had betrayed me. It must have been her plan all along, from the second shed noticed the ring on my finger that matched Damons. I should have realized it the moment Id seen her father in the room. How had I stepped into such a stupid, obvious trap? I deserved to be chained up like an animal. â€Å"Did you love her?† Damon asked, as if he could read my thoughts. I stared straight ahead. â€Å"She hasnt come to visit, in case you were curious,† Damon continued conversationally. â€Å"She is pretty, though in my humble opinion, you could do better.† Anger pushed my fangs into place. â€Å"Where are you going with this?† I growled. Damon gestured to the bars. â€Å"Nowhere, apparently. Excellent job on the rescue attempt.† â€Å"At least I tried,† I said, my fury ebbing and resignation flowing in its place. â€Å"Why even bother?† Damons eyes flashed. â€Å"Have I not made my feelings about you perfectly clear?† â€Å"I † I began, before I realized I had no idea where to even start. How could I tell him that rescuing him wasnt a choice? That our blood ran in each others veins, that we were bound to each other. â€Å"It doesnt matter,† I said. â€Å"No, it doesnt,† Damon said, adopting a philosophical tone. â€Å"After all, well both be dead soon enough. The question is, will you be killed by a crocodile or by a tiger? I heard Gallagher saying crocodiles are the best fight opponents, because they dont go for the kill. They drag it out.† Just then the attic door opened with a flourish, and Gallagher strode into the room, his boots echoing on the floor. â€Å"The vampires are awake!† he bellowed. The two guards hastily jumped to attention, pretending theyd been watching us the whole time. Gallagher strode toward the cage, kneeling at our eye level. His three-piece suit was impeccable, as if hed made his fortune as a financier rather than by torturing vampires. â€Å"Well, well, well the family resemblance is obvious. Im embarrassed to not have noticed it sooner.† He reached through the bars and grabbed the front of my shirt, pulling me against the side of the cage. My face clanged against the bars, and I winced as something wooden jutted into my chest. A stake. â€Å"And you almost got away with acting like a human!† Gallagher threw his head back and laughed, as if it were the most amusing thing in the world. â€Å"You wont get away withthis,† I hissed, pain ripping through my body as he dug the stake farther into my skin. â€Å"Pay attention, vampire!† Gallagher said, his lips curled back in a snarl. â€Å"You know, I think Im going to bet youre the one wholl get killed. Yes, I think that will do very nicely.† He turned toward the two guards. â€Å"Hear that? A tip from the boss. Bet on the dark-haired one,† Gallagher said, twisting the stake against my body. â€Å"I think his brother has more hatred in his belly.† I couldnt see Damons face, but I could picture the smirk that no doubt played on his lips. Gallagher snorted in laughter and threw the vervain-soaked stake to the floor. â€Å"Oh, and I dont want you using the stakes on the vampires for sport anymore,† he said in the direction of the guards. The heavyset one glanced guiltily down at the floor. â€Å"Why not?† the other asked indignantly. â€Å"Its good for em. Shows em their place.† â€Å"Because we want them in tip-top shape for their fight,† Gallagher said, his voice an exaggerated parody of patience. Then Gallagher smiled at us. â€Å"Thats right, boys. You two are going to be fighting, to the death. Its the perfect solution. Ill have one dead vampire to sell for parts, a live one for performances, and profit beyond my wildest imagination. You know, it might be sacrilege, but I say, thank God for vampires!† With that, Gallagher turned to leave the attic, slamming the door behind him. I sank back against the bars. Damon did the same, shutting his eyes. The two guards gaped at us through the bars. â€Å"I know the boss said the dark-haired one, there, but aint he lookin a little weak? My pennies are goin for that boy,† one commented. â€Å"Eh, I always go with what the boss says. Besides, aint all about size, right?† the scrawny one said, sounding affronted by the first guards implication. I slumped against the wall, closing my eyes. The hatred that my brother had for me was surely enough to want me dead. But would Damon really kill me? â€Å"Im more vicious than a crocodile, brother,† Damon said with a smile, his eyes still closed. â€Å"And this is the best piece of news Ive heard since we turned into vampires!† He laughed, long and loud, until one of the guards clambered over and, despite Gallaghers decree, jabbed him with a vervain-laced stake. But even then, he continued to laugh.

A Research On HIV Protease Inhibitors - Free Essay Example

Sample details Pages: 3 Words: 917 Downloads: 2 Date added: 2019/08/08 Category Medicine Essay Level High school Tags: AIDS (HIV) Essay Did you like this example? HIV Protease Inhibitors INTRODUCTION. Basically, HIV is a type of virus that attack the most importance part in the human body which is the immune system and eventually HIV virus will be converted to AIDS.   HIV LIFE CYCLE. We deal with HIV virus as a malicious type of viruses. The secret of their effect is how they hide their own DNA inside our bodys DNA, because this action will indirectly make our cells work as a large factory of producing more HIV cells and allowing more copies to be formed. Don’t waste time! Our writers will create an original "A Research On HIV Protease Inhibitors" essay for you Create order The clearest steps of HIV life cycle are six main stages: Binding (the attachment that occur between HIV proteins and CD4+ on the T4 cells) . Reverse transcription (by enzyme called reverse transcription that work on making DNA copy of the RNA that present in HIV cells) . Integration (the dissimulation of DNA that are related to HIV into the DNA in the human normal cells by an enzyme called integrase). Transcription (Formation of newly genetic material known as mRNA). Translation (making new viral proteins). Maturation (creating new HIV cells). WHATE IS HIV PROTEASE ENZYME?! Its a special type of enzymes that consist of 2 symmetrical subunits. The cleavage between a poly-alanine and tyrosine or protein is the unique function of this enzyme. The main action of protease is the inducement of human immune system as well. They can degenerate of any kind of pathogens that possibly enter the body. Also the can produce a defense effect by activation Toll-like receptors. Such researches shows that proteases are the aim and the primary target in a broad spectrum therapeutic sittings. After several researches, scantiest discover that Anti-retroviral drugs can improve the condition on HIV patients. In a very simple way we can define this type of drugs by saying that they are mainly exert there effect by preventing the virus from breakthrough body cells and start producing more copies. PROTEASE ENZYME STRUCTURE\ pep-statin. Pep-statin is the major and general inhibitor for all protease, and starting from pep-statin we discovered the most of protease enzyme inhibitor drugs. So the structure of pep-statin: PROTEASE INHIBITOR DRUGS STRUCTURE. Drugs that are approved from FDA are over 11 and more, but we will mention only two drugs with their structure: Ritonavir\ Norvir Structure: Indinavir\ crixivan Structure: MECHANISM OF ACTION FOR PROTEASE INHIBITOR. There mechanism of action is complicated, but the very main point in their effect mechanism that all protease inhibitor apply is about the binding to protease via an extensive network of hydrogen bonds, resulting in the drug become attach to the active site and this will prevent HIV reproduction. Unfortunately; mutations in HIV proteases occur frequently in a very short period so it limit the use of protease inhibitors drugs. A brief change in few Amino Acids can prevent the binding of drug to protease leading to broad drug resistance. The more strong binding of protease into drugs can be achieved by direct hydrogen bond with the backbone atoms of the iso-aminoacids at position 50 of the protease chain. PHARMACOKINETICS. Pharmacokinetics is all about absorption, distribution, and elimination. The protease-inhibitor drugs are absorbed in the gastrointestinal tract and they are PH-dependence drugs in their nature. The most of protease inhibitor drugs whatever classes they are; have high bioavailability that exceed 65%. There protein binding property is approximately 60% (as in indinavir drug). The metabolism action is locally occur in hepatic via CYP3A4, and related to the elimination half-life rate is detected clinically =1.8 hours. ADVERSE EFFECT OF PROTEASE INHIBITOR. As these drugs are dealing with one of the most serious type of viruses, there side effects are generally as following: Kidney stones. Alopecia (heavy hair loss, known also as baldness). Ingrown nails. Increase bilirubin level Extreme fatigue Distinctive oral ulceration Abnormal increase in cholesterol levels CLINICAL USE OF PROTEASE INHIBITOR DRUGS. Protease enzyme inhibitors drugs are used mainly for HIV treatment. Also for treating specific types of cancer as their strong ability on killing tumors cells in cutler. And by combination of protease inhibitor drugs with anti-protozoal may treat Malaria or some gastric infection. METABOLISM OF TWO DRUGS. About ritonavir metabolism, as we mentioned before in explanation, its mainly metabolism done by the action of CYP450. And its importance thing to mention that ritonavir drug is contraindication when patients are dealing also with rifalutin and trimethoprim drugs as these drugs are highly present in a concentered amount in the plasma body that is happened because of badly inhibition of oxidative metabolism. When talking about the metabolism action of Indinavir drug so its a little bit different story because of the glucuronide conjugation that occur in a very wide manner. The metabolism of this type of drugs are detected accurately by urine and feces samples collected from patients when doctors found that over 21% percent of the drug is excreted in the urine ( the amount of drug that shows an effect on the patient). This drug doesnt last for a long time in the human body when its taken, the half-life of it is approximately around 1.8 H. We should also mention that this drug will make a drug-interaction with ketoconazole drug and eventually lead to increase in indinavir concentration in the blood plasma. REFRENCES. https://www.ncbi.nlm.nih.gov/pubmed/12422251 https://www.researchgate.net/figure/Mechanism-of-action-of-protease-inhibitors_fig2_266592083 https://accesspharmacy.mhmedical.com/content.aspx?bookid=2189? §ionid=172486528 https://www.bocsci.com/pepstatin-a-cas-26305-03-3-item-84-88872.html?gclid=Cj0KCQiAw5_fBRCSARIsAGodhk_l4o__ElOzrbP5eR https://www.hiv.va.gov/patient/basics/what-is-HIV.asp https://www.cellsalive.com/hiv4.htm